Potentiated Embryotoxicity of Pyrimethamine by Folic Acid in Mice

Effect of pyrimethamine on folic acid metabolism in Streptococcus faecalis and Escherichia coli.

Pyrimethamine (Daraprim (Burroughs Wellcome) ; 2,4diamino-5-p-chlorophenyl-6-ethylpyrimidine) is used in the treatment and prevention of malaria (1). When used in combination with one of the sulfonamides, it is also effective in the treatment of toxoplasmosis (2) and coccidiosis (3). Pyrimethamine is one of a series of 2,4-diaminopyrimidines which have been shown to be antagonists of folic acid...

Potentiated decrease of plasma folate levels caused by the coadministration of folic acid in rats treated with methotrexate.

The decrease of plasma 5-methyltetrahydrofolic acid (5-MF) levels, postulated as an indicator of folate status, was studied following the administration of both methotrexate (MTX) alone and MTX with folic acid (FA) using rats as our experimental model. Blood and urine samples were serially collected over a 9 hr period after the administration of MTX, MTX with FA and from a control group to exam...

Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice.

Effect of Iron/Folic Acid Supplementation on the Outcome of Malaria Episodes Treated with Sulfadoxine-Pyrimethamine

Folic acid supplementation may potentially alter the efficacy of sulfadoxine-pyrimethamine (SP) treatment in children with malaria. However, there is lack of evidence from randomized controlled trials and effects of folic acid supplementation on clinical efficacy of SP therapy remain moderately understood among children. In a double masked, placebo-controlled trial among preschool children in P...

Protective Effect of Folic Acid against Apoptosis Induced by Ischemia/Reperfusion Injury in Rat Liver

       The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl-2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated controlgroup (C) (n=6), I/R group (...